miR-136 acts as a tumor suppressor by targeting various genes, including MTDH, PTEN, MAP2K4, MUC1, LRH-1, MIEN1, RASAL2, CYR61, and KLF7. It influences multiple signaling pathways, including the ...

In his Inaugural Article, Bernards describes a promising new drug combination (1). “What we describe is a gene—MAP2K4—that if you co-inhibit it with a member of the MAP kinase pathway, we get ...

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2020.

School of Medical Informatics Engineering, Anhui University of Chinese Medicine, Hefei 230012, China Anhui Computer Application Research Institute of Chinese Medicine, China Academy of Chinese Medical ...

Results: Recurrent somatic mutated genes were KRAS (63%), TP53 (59%), APC (26%), SMAD4 (19%), CDKN2A (15%), ELF3 (11%), ERBB2 (11%), ERBB3 (11%) and MAP2K4 (11%). Consistent with previous studies, all ...

Moreover, the two miRNAs co-targeted the downstream tumor suppressors MAP3K2 and MAP2K4 and subsequently achieved the HCC progression. In the clinical cohort, high expression of miR-512-3p and ...

Interleukin 6 concentration is associated with myocardial injury, heart failure, and mortality after myocardial infarction. In the Norwegian tocilizumab non–ST‐segment–elevation myocardial infarction ...

Using real-time PCR, western blotting, immunohistochemistry, and In situ hybridization, we detected the expression of miR-BART22 and MAP2K4 in tissues and cells, as well as evaluated their clinical ...