A comprehensive study of clinical and molecular features in patients with metastatic colorectal cancer with and without liver mets. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...

The MAP3K ASK1 plays a pivotal role in this process, mediating the downstream activation of MAP2K and MAP1K family proteins. Given its involvement in various neurodegenerative diseases and cancer, ...

aDepartment of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, China bDepartment of Colorectal Surgery, Fudan University ...

This important manuscript reports the cryo-EM structure of the ASK1 protein, which is a critical regulator of the MAPKs, JNKs, and p38 MAPKs in diverse cellular stress responses. The evidence of ASK1 ...

These can be risks for cancers that occur in childhood or later in life. In the case of Noonan syndrome, disease-associated variants in BRAF, KRAS, LZTR1, MAP2K, and PTPN11 genes may also confer risk ...

Ikena Oncology Inc. has disclosed mitogen-activated protein kinase kinase (MAP2K; MEK; MAPKK) inhibitors reported to be useful for the treatment of cancer.

Summary: High-frequency repetitive transcranial magnetic stimulation (rTMS) activates MAP2K signaling and enhanced axon regeneration and functional recovery following spinal cord injury. A new study ...

Metastasis is the major cause of mortality in cancer patients. Analyses of mouse models and patient data have implicated the protein kinase WNK1 as one of a handful of genes uniquely linked to a ...

Vascular malformations, affecting ≈1% to 1.5% of the population, comprise a spectrum of developmental patterning defects of capillaries, arteries, veins, and/or lymphatics. The majority of vascular ...

While no major transcriptional changes were detected , a significant (p-value<10 −2) but limited increase in expression (0 < log 2 [Fold Change]<1) of multiple regulators of gametogony (including ...

Influence of chronic neuropathic pain on VEGFA in tumors of mice with genetically determined inhibition of tumor growth. This is an ASCO Meeting Abstract from the 2020 ASCO Annual Meeting I. This ...