Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

The MYC transcription factors (c-MYC, L-MYC and N-MYC) are well-established drivers of human cancers that maintain high levels of protein translation, which is critical for uncontrolled cell ...

This important study using engineered mouse models provides a first compelling demonstration of a pathogenic phenotype associated with lack of expression of p53AS, an isoform of the p53 protein with a ...

Scale bars, 50 μm. Expression of MYC, p53, and KRAS G12D was detected in the iHCC samples (n = 3, biological replicates) by Western blotting. Cropped blots are shown. J. Immunofluorescence analysis of ...

While the authors did not examine the metabolic changes associated with macrophage polarization, they demonstrated an antagonistic interaction between p53 and c-Myc involved in the regulation of M2 ...

AMPK activity predominantly stimulates catabolic reactions, generating conflicting signals with the MYC-induced anabolic pathways (depicted in the figure, see text for details). The metabolic stress ...

Using unbiased transcriptomic and proteomic analyses, the transcription factors p53 and c-MYC are identified as having defining roles in CML LSC survival. We demonstrate an integral relationship ...

Here, we show that Myc-induced altered glutamine metabolism involves ATP depletion and activation of the energy sensor AMP-activated protein kinase (AMPK), which induces stabilizing phosphorylation of ...