Bianca Gonzalez opened up about her internal struggles as a host, sharing how she remains her own toughest critic. In an ...

Researchers are now devising strategies to target MYC directly by interfering with the MYC-MAX protein complex, which activates numerous cancer-related genes. Promising compounds, such as OMO-103 ...

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States Center for Pharmaceutical Research and Innovation, Department of Pharmaceutical Sciences, College of Pharmacy, ...

a known small molecule for disrupting c-Myc–Max inhibition, through the Sn-2 acyl position of an oxidized lipid. PDs were formulated in tiny polysorbate particles (20 nm) and perfluorocarbon ...

C-Myc, a transcription factor, is increased in vascular smooth muscle cells following vascular injury. Anti-sense oligonucleotides (AS-ODN) have been shown to inhibit c-Myc and reduce stenosis in ...

C) X-ray structure of MYC:MAX heterodimer binding DNA (PDB ID: 1NKP). This review describes the main functional and structural features of the MYC protein, delineates the most relevant or recently ...

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The supernatant fraction was incubated with the anti-MYC (Santa Cruz Biotechnology, Shanghai, China) or anti-MAX (Cell Signaling Technology) antibodies overnight at 4°C with rotation. Mouse IgG served ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Eukaryotic transcription factors recognize ...