Background A polymorphism (rs35705950) 3 kb upstream of MUC5B , the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF). We ...

Pulmonary fibrosis (PF) is a progressive interstitial lung disease (ILD) characterised by excessive fibrotic tissue deposition in the pulmonary parenchyma. The term "pulmonary" refers to the lungs ...

MUC5B encodes a mucin protein involved in airway mucus production. The rs35705950 variant is a gain-of-function mutation in the gene’s promoter region, leading to elevated MUC5B expression.

The MUC5B mucin is clearly forming linear molecules as confirmed by electron microscopy (Ermund et al, 2017; Ridley et al, 2016). The MUC5AC mucin on the other hand forms net-like structures ...

A RECENT study has uncovered a new connection between genetic risk factors for idiopathic pulmonary fibrosis (IPF) and the development of post-COVID-19 lung abnormalities, suggesting a possible ...

The effect of pollution exposure on IPF severity and progression was not modified by MUC5B promotor polymorphism or telomere length. Long-term exposure to fine particulate matter is associated ...

One such gene is MUC5B, this makes a mucus protein which helps clear harmful substances, like bacteria, from the lungs. NIH said that having a mutated version of this gene increases the risk for ...

The following is a summary of “MUC5B Promoter Variant and Survival in Rheumatoid Arthritis-Associated Interstitial Lung Disease,” published in the November 2024 issue of Rheumatology by Klein et al.

ABSTRACT: Oral health is an important aspect of athletes’ overall health, yet it is often overlooked. Dental pain and its pharmacological treatment can have an impact on athletic performance, leading ...

When the researchers reduced sialic acid on MUC5B, they observed a change in the electrophoretic mobility for the protein indicative of a lower charged form. Transmission electron microscope imaging ...

MUC5B secretion. According to BBC Science Focus, performing all kinds of intense exercise increases the amount of protein that the body secretes into the saliva. In particular, the body specifically ...

These data indicate that increased MUC5AC concentration in the airways might contribute to COPD initiation, progression, exacerbation risk, and overall pathogenesis. Compared with MUC5B, greater ...