The VPS35/Retromer complex plays a crucial role in regulating MT1-MMP, an enzyme essential for cancer metastasis, by controlling both its stability and recycling. The complex binds to MT1-MMP ...

“The additional imaging data using an early BRC molecule continue to validate the potential of MT1-MMP as a novel cancer target, demonstrate the translatability of our preclinical data and ...

"The additional imaging data using an early BRC molecule continue to validate the potential of MT1-MMP as a novel cancer target, demonstrate the translatability of our preclinical data and position ...

CAMBRIDGE, England & BOSTON, April 29, 2025--(BUSINESS WIRE)--Bicycle Therapeutics plc (NASDAQ: BCYC), a biopharmaceutical company pioneering a new and differentiated class of therapeutics based ...

Additionally, our encouraging first human imaging data for MT1-MMP demonstrates the potential of our technology platform to produce radiopharmaceutical medicines to novel targets," said Bicycle ...

The company’s Bicycle Toxin Conjugates (BTC) pipeline includes zelenectide pevedotin, BT1718 and BT5528 to indicate metastatic urothelial cancer, epha2 (ephrin type-a receptor 2), MT1-MMP (membrane ...

Additionally, last week we shared exciting first human imaging data for our first radiopharmaceuticals molecule, validating the potential of MT1-MMP as a novel cancer target and providing ...

One significant protein, CD63, has been demonstrated to contribute to these processes by facilitating the lysosomal degradation of Membrane-type 1 matrix metalloproteinase (MT1-MMP). Epithelial ...

Membrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice ...

The results demonstrate that MT1-MMP is a major host factor that mediates the cell entry of SARS-CoV-2, and that it is also a potential therapeutic target for COVID-19 drugs.