Through an unbiased genomewide KO screen, the authors identified loss of DBT to suppress MG132-mediated death of cultured RPE cells. Further analyses suggested that DBT reduces ubiquitinated proteins ...

This important study discovered DBT as a novel gene implicated in the resistance to MG132-mediated cytotoxicity and potentially also in the pathogenesis of ALS and FTD, two fatal neurodegenerative ...

CM90P CM 5.3 x 4.9mm with 23 user I/Os, 128MBit PSRAM, no MIPI C-PHY MG132P MBGA – 8x8mm with 38 user I/Os, 64Mbit SPRAM GW5ANT-15 – MG132 MBGA 8x8mm with 47 user I/Os, 8Mbit NOR flash GW5ANRT-15 – ...

If degradation of PNPLA3 is dependent on ubiquitylation by a single E3 ubiquitin ligase, then inactivation of that E3 ligase should increase PNPLA3 levels to the same extent as those observed with ...

A recent study published in the Cell Chemical Biology Journal described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells. PCNA is a ...

The UPS inhibitor MG132 and autophagy inhibitor 3-MA (3-methyladenine) were administered to mice to identify how BAG3 was involved after MCAO/R. Adeno-associated virus and lentiviral vector were used ...

B. (left) SRM images of paraspeckles in HAP1 NEAT1 Δ3′ mutant cells (Δ3′) detected by NEAT1_5′ (green) and NEAT1_15k (magenta) FISH probes in the presence of MG132 (5 μM for 6 h). Scale bar, 500 nm.

The majority were rescued from degradation by MG132, which is known to inhibit lysosomal cathepsins in addition to the proteasome. Global definition of the precise mechanisms of host protein ...

Cells were lysed at the indicated time points followed by Western blot analysis. MG132 (A2585, Apexbio) is stored at -20°C at a concentration of 10 mM diluted in dimethyl sulfoxide (DMSO). MG132 and ...