These included MEK1 and MEK2, which control a pathway called ERK involved in cellular division and survival, and MEK3 and MEK6, which regulate the p38 pathway that’s involved in stress-induced defense ...

These included MEK1 and MEK2, which control a pathway called ERK involved in cellular division and survival, and MEK3 and MEK6, which regulate the p38 pathway that’s involved in stress-induced ...

Once activated, Raf serine-phosphorylates MEK1 and MEK2, which in turn phosphorylate ERK. There is also substantial cross-talk at the Raf1 level between the Raf-MEK-ERK pathway and the pathway of ...

Accordingly, inhibition of the ERK pathway using a small compound inhibitor or conditional deletion of the MAP2Ks Map2k1 (MEK1) and Map2k2 (MEK2), in mature osteoblasts and osteocytes, markedly ...

vtRNA functions as a putative riboregulator of synaptogenesis. vtRNA binds to and activates MEK1, thereby enhancing MEK1-mediated ERK activation in neurites. Activation of ERK signaling promotes local ...

In addition to desensitizing and internalizing G protein–coupled receptors, arrestins mediate ERK1/2 activation by scaffolding three kinases: ERK1/2, MEK1, and Raf. The structural mechanism by which ...

Conversely, overexpression of a constitutively active mutant of MEK1 increased EC migration and proliferation, which were comparable to those of ECs stimulated with FGF-2. LysoPC inhibited ...

MEK1/2 inhibition inactivates ERK1/2 and also ... preclinical and clinical trials for various cancers in which MAPK/ERK is overactive especially BRAF-mutated melanomas and KRAS/BRAF mutated ...

Triggering of BCR-like and PKC signaling in pDCs resulted in an upregulation of the expression and phoshorylation of c-FOS, a downstream gene product of the MEK1/2-ERK pathway. We found that the total ...