elegans homolog of MAPKKK ASK1) and insulin signaling in this process. Overall, I am not convinced that the authors have provided sufficient evidence to support the various components of their ...

The MAPKKK-MAPKK-MAPK phosphorylation cascade is facilitated by scaffold proteins, which bind members of the MAPKKK, MAPKK and MAPK families in close proximity. There is a variety of different MAPKKK, ...

Biomolecular NMR and Drug Discovery Laboratory, Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551, and Biotechnology ...

Activated transmembrane receptors directly activate intracellular signaling proteins, including G proteins (Gq/11) and the Grb2-SOS complex, which promote activation of the MAPK cascades: MAPK kinase ...

In normal cells, upon the binding of external stimuli, activated Ras relays the signals through a RAF-MEK-ERK (MAPKKK-MAPKK-MAPK) phosphorylation cascade, leading to MAPK pathway activation. On the ...

Neurons require compartmentalized actions of molecules to sustain function under various stress conditions. The conserved MAPKKK DLKs are key stress-sensing kinases extensively studied for their roles ...

We greatly appreciate discussions with P. Sengupta and her lab members, as well as A.D. Chisholm, G. Ou, and C.-Y. Su for comments on the manuscript. We thank P. Sengupta, M. Leroux, G. Ou, and A.

MAPKKK, MAPKK kinase; ERK5, extracellular regulated protein kinases 5; IκB, inhibitor of NF-κB protein; GSH, glutathione; NSCLC, non-small cell lung cancer; NQO1, NAD(P)H quinone dehydrogenase 1; ...

Thought LeadersXinxing Zhang, Ph.D.Postdoctoral Research Fellow University of Michigan In this interview, News-Medical speaks to Xinxing Zhang, a postdoctoral research fellow at the University of ...

MAPKKK, MAPK kinase kinase; c-Jun, c-Jun N-terminal kinase; cyt-C, cytochrome C. Overall, this review of anti-apoptotic mechanisms of ginsenoside in MIRI presents pharmacological mechanisms and lays ...

is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its ...

via a three-tiered kinase cascade (MAPK cascade) composed of a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK), and a MAPK. MAPK pathways commonly comprise, in addition to the core MAPK cascade ...