Similarly, the overexpression of lncRNAs like MALAT1 in TAFs has been linked to enhanced migration and invasiveness of ovarian epithelial carcinoma cells. TAFs are also involved in the development ...

This impacts access to BibTeX and RIS files. This is an important and convincing dataset shedding new light on a role for Malat1 in osteoblast physiology. The work is of value to areas other than the ...

The monovalent ion concentration was selected based on where changes in MALAT1 triplex stability are most clearly observed. (16) A total of eight experiments were prepared and dispensed in eight ...

DNL310 is currently in phase 3 trials. To test the approach with ASOs, Denali scientists chose to focus on a gene called malat1. “It's a commonly used target in the field for proof-of-concept ...

One such lncRNA of interest is MALAT1, abbreviated for metastasis-associated lung adenocarcinoma transcript 1. Initially noted for its impact on gene expression in non-small-cell lung cancer cells ...

Recent genome-wide association studies identified an association between low bone mineral density (BMD) and a single-nucleotide polymorphism (SNP) at the MALAT1 locus, but there is no functional ...

Silencing this molecule, called Malat1, in mice with breast cancer reduced metastases and improved survival, suggesting that a similar treatment could benefit patients. What controls this ...

Here, we report that targeting metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an oncogenic long noncoding RNA (lncRNA), contrives a BRCAness-like phenotype, and augments sensitivity ...

Wheeler et al. have discovered a new RNA circuit that regulates T-cell function. They found that the long non-coding RNA Malat1 sponges miR-15/16, which controls many genes related to T cell ...

Researchers from the University of Texas and University of Tennessee set out to determine if the long noncoding RNA (lncRNA) MALAT1 (metastasis associated lung adenocarcinoma transcript 1), which is ...

They found that MALAT1, a gene associated with metastasis in lung, bladder and other cancers, was highly present in leader cells. Importantly, Wong said, MALAT1 expression increased when a cancer cell ...