During the early stages of research and development, Moderna and Pfizer tested their vaccines in the lab using HEK 293 cells, a cell line originally derived from a 1973 abortion in the Netherlands.

To determine the effects of SUMO2-p66ShcK81 on vascular function, we generated p66ShcK81R knockin mice and crossbred to LDLr-/-mice to induce hyperlipidemia ... (A) Immunoblot for sumoylated p66Shc in ...

Canterbury Equestrian owner Sharon Jones said she felt "disgusted" at the treatment of her company by Rangiora firm Newzealandnz, but its owner, Danny de Hek, insisted the website was rightfully ...

They found that the LC neurons express higher levels of LDLR, part of a receptor called sigma-2 that helps cells take in cholesterol molecules. A consequence of this is that toxic amyloid-beta ...

Hek is a character in the Netflix miniseries Apple Cider Vinegar, which draws inspiration from the real-life crisis manager of Belle Gibson. The show takes some liberties with Gibson's narrative ...

The Gist: In 2015, we see Belle Gibson meeting with Hek (Phoenix Raei), a crisis management expert, after she was outed for her lies. She insists to Hek that she actually had cancer and wants to ...

As more people apply for religious exemptions to vaccine mandates, experts explain how and why fetal cells are used in drug development, from vaccines to common pain medications. “So many people ...

It transports cholesterol, with most clearance mediated by LDLRs on hepatocytes. Disruptions in LDLR function or apoB100 mutations, as seen in FH, lead to low-density lipoprotein cholesterol (LDL ...

Until now scientists have been unable to visualize the structure of LDL, specifically what happens when it links up with its receptor, a protein known as LDLR. Typically, when LDL binds to LDLR ...

(Comments below.) LDLR: An ApoE Gateway Researchers have long known that ApoE2 binds weakly to low-density lipoprotein receptor. But many have assumed that if that were important for AD pathology, ...

LDLR is synthesized in the endoplasmic reticulum (ER ... sensitivity and resistance assay and Western blotting analysis (described in subsequent sections), HEK293T cells (HEK-293T; ATCC, Manassas, VA, ...

HEK-293T cells were cultured in Dulbecco's Modified Eagle Medium ... The membranes were incubated with primary antibodies to LDLR (Abcam, Cambridge, UK), PCSK9 (R&D Systems, Minneapolis, MN, USA) ...