Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor-related protein (LRP) coreceptor (e.g., LRP5) but is inhibited by the binding of ...

Newly granted patent is part of the expanding intellectual property portfolio directed to: -generating novel and selective Wnt surrogate molecules with potentially broad therapeutic utility and ...

In this case, researchers from the Advanced Centre for Treatment, Research, and Education in Cancer (ACTREC), Mumbai were able to identify the fusion transcript (UBE3C-LRP5) as well as map the ...

Lrp5, a known low-density receptor-related protein, plays an essential role in cellular proliferation and osteoblastogenesis via the β-catenin signaling pathway. We hypothesize that Lrp5 also plays a ...

The partnership, valued at nearly $600 million, centers on Surrozen’s developmental compound SZN-413, a bi-specific antibody targeting Fzd4-mediated and LRP5 Wnt signaling. The alliance will combine ...

Their new publication describes how one of the antibodies, specifically activating the Frizzled4-LRP5 receptor complex, successfully stimulated Wnt signaling in the blood-retina barrier and ...

The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–barrier during development ...

In vertebrates, low density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6), the single-pass transmembrane proteins, act as coreceptors of Wnt ligands and are indispensable for Wnt ...