Chad Kassem is on a mission — saving listeners “from bad sound” — at the rural factory where he pores over LPs from some of music’s most important artists.

Here, we reveal that upon lipopolysaccharide (LPS) stimulation, lysine acetyltransferase CBP is recruited to the TLR4 signalosome complex leading to increased acetylation of the TIR domains of the ...

IRF3 KO mice are resistant to LPS-induced endotoxin shock . Because these mice were found another null mutation in the Bcl2l12 gene, Taniguchi et al. further showed that selective IRF3 deficiency in ...

Since IRF3‐Thr207 has no impact on IRF3 dimerization, we could speculate that like WT IRF3, IRF3‐Thr207 is recruited to and then dissociated from the other adaptor proteins (STING/TRIF/TBK1). In ...

4) More single cell immunofluorescence results of NF-κB nuclear translocation (cGAMP and LPS inducer) and IRF3 nuclear translocation (LPS inducer) are needed to further dissect the role of Vpr. In our ...

Figure 1. The expression profiles of IRF3, IRF8 and MyD88 in liver after lipopolysaccharide (LPS) and Vibrio induction. The expression profiles of IRF3, IRF8, and MyD88 has been analyzed in liver at 3 ...

TLR-induced suppression of IRF3 by MKP proteins. (A, Left) PLA for IRF3–MKP1 or IRF3–MKP5 complex in peritoneal macrophages stimulated for 4 h with LPS, B-DNA, or B-DNA plus LPS. Red spots indicate ...

IRF3 activation by LPS and polyI:C occurs in a Toll/IL-1R domain-containing, adaptor-inducing IFN-β(TRIF)-dependent manner 5, 10. On dsRNA binding, TLR3 recruits adapter protein TRIF.