Two Patients With Advanced-Stage Lung Adenocarcinoma With Radiologic Complete Response to Nivolumab Treatment Harboring an STK11/LKB1 Mutation. JCO Precis Oncol 4 , 1239-1245 (2020). DOI: ...

Howard Colman, MD, PhD, has multiple clinical interests including the treatment of primary and metastatic brain tumors, and the diagnosis and management of neurologic complications of cancer. His ...

Hypermethylation of the LKB1 promoter is associated with tumorigenesis, while genomic alterations of the LKB1 gene such as deletions, rearrangements, and splicing, can produce truncated proteins.

Mutations in serine-threonine kinase 11 (STK11) and liver kinase B1 (LKB1) are associated with disease progression in Peutz-Jeghers syndrome (PJS), which can progress to cancer.

However, other findings suggest that LKB1 promotes tumorigenesis through activating ROS scavenging, DNA repair machinery, and autophagy, highlighting its paradoxical role in tumor biology.

These include NSCLC tumors that carry mutations in both the KRAS and LKB1 genes. Patients with this type of cancer, known as KL mutant NSCLC, have limited treatment options if their tumors don’t ...

A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101402, discusses insights into targeting LKB1 in tumorigenesis.. Genetic alterations to serine-threonine kinase 11 (STK11) have been ...

A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101402, discusses insights into targeting LKB1 in tumorigenesis.

A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101402, discusses insights into targeting LKB1 in tumorigenesis.

The tumor suppressor gene LKB1 (STK11) encodes a serine/threonine protein kinase that is inactivated in several types of human cancers, including up to 30% of lung adenocarcinomas (LUAD) ().Tumors ...

Metformin and Weight Loss If you’ve been diagnosed with type 2 diabetes, metformin may be the first medication your doctor recommends. Research shows that it helps with blood sugar control by ...