LMO2 and LMO4 are members of a small family of nuclear transcriptional regulators that are important for both normal development and disease processes. LMO2 is essential for hemopoiesis and ...

These cells, known as LMO2+ cells, only make up one to two percent of tumor cells. But their impact is major. Cells that express the LMO2 gene exhibit more plasticity—the ability to change ...

To confirm the necessity of LMO2 for the maintenance of the differentiation capacity into T-cell lineage, we tested the effect of Lmo2 disruption on the developmental potential of T-cell lineage in ...

Clusters 27 and 43 are both hematopoietic lineages, based on their expression of TAL1 and LMO2. Cluster 27 is likely the Intermediate Cell Mass (erythroid lineage) based on its expression of GATA1A, ...

Finally, further studies to investigate the mechanisms involving the influence of LMO2, IL10, and GSTM1 genes upon PTS and childhood asthma development are needed. The raw data supporting the ...

Dr Mansour and colleagues went on to widen their search, identifying other oncogenes affected by non-coding mutations, such as LMO2, in which small insertions generated a new enhancer element [3].

We found that a heptad of transcription factors (Runx1, Gata2, Tal1, Fli1, Lyl1, Erg and Lmo2) is specifically co-expressed in an intermediate population expressing both endothelial and hematopoietic ...

The approach taken that linked LMO2 to SPHK1 (sphingosine kinase 1) was interesting. Using a mouse LMO2 CHIP-Seq analysis, the authors show that LMO2 has binding regions in VEGF-A (vascular ...

We focus on the oncogenic transcription factors TAL1, LMO2, and NOTCH1 and highlight the significance of the transcriptional regulatory programs in normal hematopoietic stem cells and T-ALL. Although ...