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We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP‐activated protein kinase ...

A brief overview of the physiological and pathological role of LKB1 signaling. Mutations in serine-threonine kinase 11 (STK11) and liver kinase B1 (LKB1) are associated with disease progression in ...

Mutations in serine-threonine kinase 11 (STK11) and liver kinase B1 (LKB1) are associated with disease progression in Peutz-Jeghers syndrome (PJS), which can progress to cancer. Previous studies ...

These include NSCLC tumors that carry mutations in both the KRAS and LKB1 genes. Patients with this type of cancer, known as KL mutant NSCLC, have limited treatment options if their tumors don't ...

These include NSCLC tumors that carry mutations in both the KRAS and LKB1 genes. Patients with this type of cancer, known as KL mutant NSCLC, have limited treatment options if their tumors don’t ...

A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101402, discusses insights into targeting LKB1 in tumorigenesis. Genetic alterations to serine-threonine kinase 11 (STK11) have been ...

A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101402, discusses insights into targeting LKB1 in tumorigenesis. Genetic alterations to serine-threonine kinase 11 (STK11 ...

“For non-small cell lung cancer cases with the LKB1 mutation, standard chemotherapy and immunotherapy treatments are not effective,” senior and co-corresponding author Reuben Shaw, Ph.D ...

“For NSCLC cases with the LKB1 mutation, standard chemotherapy and immunotherapy treatments are not effective,” said research lead Reuben Shaw, PhD, who is a director of Salk’s Cancer Center.

The findings were published in Science Advances on March 17, 2023. "For non-small cell lung cancer cases with the LKB1 mutation, standard chemotherapy and immunotherapy treatments are not ...