Here we show that long transcripts encoded from the Kcnq1ot1 antisense promoter silence the flanking genes more efficiently than short antisense transcripts. Interestingly, the antisense RNA‐mediated ...

seekr_download_gencode lncRNA -g -r 43 -s human seekr_filter_gencode v43_lncRNA.fa -gtf v43_lncRNA.chr_patch_hapl_scaff.annotation.gtf -len 500 -can -rd -o v43_canonical Estimate a p value for the ...

KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), a long non-coding RNA, has been unmasked to participate in the pathogenesis of DN. However, the specific mechanism by which KCNQ1OT1 regulates ...

The experiment was repeated three times. The binding relation between Kcnq1ot1 and miR-204-5p was verified in the same way. The wild-type sequence or mutant sequence of Kcnq1ot1 was, respectively, ...

[a ]College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR China [b ]Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of ...

Quantitative reverse transcription PCR (RT-qPCR) was used to quantify KCNQ1OT1, miR-30a-5p, ubiquitin-specific peptidase 22 (USP22), and programmed death-ligand 1 (PD-L1). The interactive relationship ...

As a dominant cardiovascular disease, myocardial infarction (MI) causes a considerable mortality globally. KCNQ1 overlapping transcript 1 (KCNQ1OT1) was reported to be overexpressed in MI patients.

A complete hydatidiform mole (CHM) is a conceptus with only sperm-derived chromosomes. Here, we report on a CHM with genomic DNA identical to that of the paternal somatic cells. The CHM developed ...