Cdc25C‐associated kinase 1 (C‐TAK1) has been implicated in cell cycle regulation and Ras signaling through its interactions with two putative substrates, the Cdc25C phosphatase and the MAPK scaffold ...

aState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen ...

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South ...

Well, that was exciting, wasn’t it? An incredibly close contest for the overall victory in the Timed Shootout at the 2023 Goodwood Festival of Speed presented by Mastercard has been won by the McLaren ...

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong ...

Introduction: Cardiac fibroblasts (CFs) have a crucial role in ECM remodeling as well as influencing contractility through crosstalk with the cardiomyocytes. There is accumulating evidence that the ...

1 Institute of Physiology of the Czech Academy of Sciences, Laboratory of Structural Biology of Signaling Proteins, Division BIOCEV, Vestec, Czechia 2 Department of Physical and Macromolecular ...

Here, we show that KSR1 and ERK promote EMT-like phenotype through the preferential translation of Epithelial-Stromal Interaction 1 (EPSTI1), which is required to induce the switch from E- to ...

This paper demonstrates the involvement of Kinase Suppressor of Ras 1 (KSR1), a protein that acts as a scaffold in the mitogen-activated protein kinase (MAPK) signaling cascade, in translational ...

1Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

FLAG‐tagged CRAF was immunoprecipitated (IP), and the immunocomplexes were Western‐blotted for endogenous KSR1 (left panel), endogenous KSR2 (right panel), and FLAG. Endogenous KSR1 (left panel), ...