A recent publication in Current Issues in Molecular Biology, titled “Krüppel-like Factor 4-Deficient Cells Are Sensitive to Etoposide-Induced DNA Damage,” examines the role of the gene KLF4 in DNA ...

Both miR-128 and miR-148a target a gene called KLF4, which is associated with inflammatory control and the production of cytokines that regulate the activity of the immune system. "Assuming that ...

Both miR-128 and miR-148a target a gene called KLF4, which is associated with inflammatory control and the production of cytokines that regulate the activity of the immune system. Assuming that ...

Professor Seong and researcher Na first demonstrated that Klf4 works as a key factor in regulating CD8 T cell activity within cancer tissue, and Klf4 effectively removes cancer cells without ...

Modulation of a single amino acid in the reprogramming factor Kruppel-like factor 4 (KLF4) has been demonstrated to markedly improve natural transcription factor function and to result in faster and ...

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression. The study, ...

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression. The study ...

In this study, we showed that the KLF4 expression was downregulated in human breast cancer tissues, which was associated with hypermethylation of its promoter region. DIM could enhance PTX sensitivity ...

Here, we reported that abridged miR-135a expression in OS cells and tissues, and its expression is inversely correlated with the expression of BMI1 and KLF4, which are described as oncogenes in ...

For their work, the team used an adeno-associated virus (AAV) as a vehicle to deliver into the retinas of mice three youth-restoring genes -- Oct4, Sox2 and Klf4 -- that are normally switched on ...