Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also known as p53, which serves as a crucial cell protector. This protein acts a ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumors FMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

An imbalance of antiproliferative BMP (bone morphogenetic protein) signaling and proliferative TGF-β (transforming growth factor-β) signaling is implicated in the development of pulmonary arterial ...

[Keith Chambers/Science Photo Library/Getty Images] The p53 protein plays a significant role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long ...

In a recent study published in the Cell Reports journal, researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition. Studies have shown that exposing esophageal cells ...

Corsair’s K63 compact mechanical gaming keyboard sports a “tenkeyless” form factor, meaning its shorter in width due to the removal of the numeric keypad. That also means the peripheral is ...

New research led by the University of Bristol has found the protein p53 plays a key role in epithelial migration and tissue repair. The findings could improve our understanding of the processes used ...

The researchers demonstrated that when used in combination with immune checkpoint blockade (ICB), the p53 mRNA nanoparticle technology—which is similar to that used in COVID-19 vaccines—not ...

p53 binds to the p53 promoter regions where it initiates the ... and RNF168 to catalyze the attachment of K63-polyubiquitin chains onto histones at the site of damaged DNA. This HERC2-mediated ...