Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.

The company’s aim to focus on JNK inhibitors with greater specificity for JNK1 and JNK3 than for JNK2 led it to license lead compounds from Baylor College of Medicine.

Introduction: Aging is an independent risk factor for atrial fibrillation (AF). We recently revealed a critical role of activated cardiac stress kinase JNK2 in AF risk. Yet, the mechanisms underlying ...

Researchers at the Ohio State University College of Medicine found that binge drinking-related arrhythmias are linked to increased levels of a stress-induced protein called JNK2. This can cause ...

The new study suggests, for the first time, that the molecule Alda-1 may prevent the activation of JNK2 that leads to AFib. The study found: In this study, more than 70% of the mice that were ...

Previous animal research by this research team found binge-drinking-related arrhythmias are induced by elevations in a stress-induced protein called JNK2. This can cause heart cells to mishandle ...

Previous animal research by this research team found binge-drinking-related arrhythmias are induced by elevations in a stress-induced protein called JNK2. This can cause heart cells to mishandle ...

Correspondence to Dr Richard F Loeser, Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA; ...

This paper is of great interest as a serendipitous discovery that, in the course of investigating the physiological role of granzyme A, has revealed the significance of the Nnt gene mutation in the ...

We previously reported that c-Jun N-terminal protein kinase 2 (JNK2) promotes stress-induced mitophagy by targeting small mitochondrial alternative reading frame (smARF) for ubiquitin-mediated ...

JNK proteins consist of 10 isoforms which are derived from 3 genes. JNK1 has four, JNK2 has two, and likewise, there are two JNK3 isoforms. Depending on how the 3’ coding region of the ...

MC3T3–E1 cells were collected and subjected to fluorescence-activated cell sorting (FACS) assay at 48 h post-transfection. We used non-transfected MC3T3–E1 cells as negative control, among the ...