“On average, Nepal receives only IRs1.8 billion from the allocated amount, and even that is mostly spent on political gatherings as it is distributed through the Indian Embassy. It does not contribute ...

NT219, a novel dual inhibitor of IRS1/2 and STAT3, is being evaluated in a Phase 2 study in patients with recurrent and/or metastatic head and neck squamous cell cancer (R/M HNSCC) in combination with ...

Purple Biotech’s NT219 is a first-in-class small molecule drug designed to target key cancer resistance mechanisms by degrading IRS1/2 and blocking IGF1R/IRS1 and STAT3 survival pathways.

1 The dose expansion study demonstrated that NT219, a dual inhibitor of STAT3 and IRS1/2, in combination with cetuximab, was well tolerated and demonstrated a manageable safety profile. Dose levels at ...

Other infrastructure projects that India is currently implementing in Nepal are the East-West fibre optics (IRs740 million), the integrated check-posts at Birgunj (with IRs1.3519 billion spent on ...

Removal of ovaries leads to the death of female cardiac IRS1/2 double genes knockout mice. Sex hormone estrogen enhances cardiac function, promotes energy metabolism, prevents dilated cardiomyopathy, ...

GRAPHICAL ABSTRACT. Erchen Decoction could inhibit excessive lipolysis and improve lipid metabolism disorders by regulating the IRS1/AKT/PKA/HSL signaling pathway in white adipose tissue of ZDF rats.

Phosphorylation results in the depletion of plasma membrane-localised IRS1/2, reducing the pool available for interaction with the insulin receptor. Together these events limit plasma ...

Mechanistically, TFEB upregulates IRS1 and IRS2 (insulin receptor substrate 1 and 2). TFEB increases IRS2 transcription measured by reporter gene and chromatin immunoprecipitation assays. Furthermore, ...

The insulin receptor substrate 1 (IRS1) and ectonucleotide pyrophosphate phosphodiesterase (ENPP1) genes play crucial roles in controlling cell signaling in response to insulin. Once insulin binds to ...

They can also interact with several growth hormone receptors that are strongly correlated with tumour growth [11]. IRS1 is the first member of this family and is widely expressed in human tissues.