The sequencing results showed a crucial difference between the two cell populations: the expression of the gene IRF1. IRF1 stands for Interferon Regulatory Factor 1. "IRF1 is a transcription ...

The study, published in Cell Reports, reveals how IRF1 can both hinder and help the body's immune response to tumors, depending upon which cells the protein is found in. "We know IRF1 plays a ...

They found that the presence of IRF1 in tumor cells can actually weaken the immune response by promoting T cell exhaustion and by affecting toll-like receptor and type-I interferon responses. This ...

The distinct transcriptional properties of ISGF3 and IRF1 correspond with a largely diverse nuclear protein interactome. Mechanistically, we describe the specific input of ISGF3 and IRF1 into enhancer ...

Interferon regulatory factor 1 (IRF1) plays an essential role as a transcription factor in driving the expression of immune response genes during infection. The striking difference in functional ...

We also verified the differential allele-specific binding to H3K27Ac, H3K3Me1, P300, PARP1, and IRF1 against rs13385731 using ChIP-qPCR (figure 1). Interestingly, while PARP1 binding affinity is ...

These control a subset of cytokine regulatory factor genes including IFN response factor 1 (IRF1), CSF2, NFKB1A and DUSP10. Focusing on the downstream role of IRF1, selective knockdown (KD) and ...

Effect of doxorubicin on efficacy of immune checkpoint inhibitors through increasing infiltration of CD8-positive T cells and activating STAT1-IRF1-CXCL10 axis. This is an ASCO Meeting Abstract from ...

It's made up of a complex network of organs, cells, and proteins - like IRF1 or regulatory factor 1, which is key in the regulation of an early immune response to pathogens," says co-author of the ...

CNNM2 indicates cyclin and CBS domain divalent metal cation transport mediator 2; IRF1, interferon regulatory factor 1; IVW, inverse variance weighted; MR, Mendelian randomization; OR, odds ratio; and ...

Here, we show that the interferon regulatory factor 1, Irf1, is directly controlled by the murine formative pluripotency gene regulatory network and transiently upregulated during the transition from ...