The pairwise comparison analysis (p<0.05) for GR-bound genes across BL and DLBCL cell lines revealed a significant enrichment of negative regulators of BCR/PI3K signaling and BCR-related tumor ...

At his own company, Lamb added, the team is initially targeting the PLCG2 and INPP5D genes, both of which are downstream of TREM2 and also have genetic associations with Alzheimer’s disease.

INPP5D makes the protein SHIP1, a membrane-associated phosphatase that dampens cell-signaling pathways. Inhibiting microglial AD gene INPP5D activates the inflammasome. In AD brain, INPP5D expression ...

The team revealed that a reduction of INPP5D, a gene found in microglia, results in neuroinflammation and increases the risk for AD. Their results, which have important implications for the design of ...

A decrease in INPP5D, a gene found in microglia, induces neuroinflammation and increases the risk of Alzheimer's disease, according to the study. Brigham and Women's Hospital researchers findings ...

Genetic Insights: The Impact of the INPP5D Gene The research team made a groundbreaking discovery about the INPP5D gene found in microglia. They found that reduced levels of INPP5D lead to ...

The team revealed that a reduction of INPP5D, a gene found in microglia, results in neuroinflammation and increases the risk for AD. Their results, which have important implications for the design of ...

Brigham researchers have discovered that a reduction in the INPP5D gene in microglia leads to increased neuroinflammation, potentially contributing to the progression of Alzheimer’s disease, paving ...

Previous studies suggested that the inositol polyphosphate-5-phosphatase D (INPP5D) gene, expressed in microglia, was associated with Alzheimer’s risk, so that’s what the researchers looked into.

Using several experimental approaches, scientists at Brigham and Women’s Hospital have probed the relationship between levels of INPP5D and a specific type of brain inflammation, activation of the ...

The researchers discovered that a decrease in INPP5D, a gene located in microglia, causes neuroinflammation and raises the risk of Alzheimer's disease. Advt Brigham and Women's Hospital ...