Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. TP53 mutations in AML confer resistance to CAR ...

Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal models have shown that cholesterol and inflammation are causatively involved in the disease process.

The strategy: introduce a normal copy of the faulty gene, designated IL2RG, into a patient’s own stem cells, which then go on to produce the immune system components needed to fight infection.

In a fascinating new study, scientists created fully-functional mini-livers out of human skin cells, then successfully transplanted them into rats. The research is a proof-of-concept for ...

Despite enormous advances, cardiovascular disorders are still a major threat to global health and are responsible for one-third of deaths worldwide. Research for new therapeutics and the investigation ...

The natural history of his disease suggests considering IL2RG variants as a potential cause of “X-linked recessive Mendelian susceptibility to mycobacterial disease.” His reactive lymphohistiocytic ...

The patient was found to have a pathogenic germline mutation in the X-linked interleukin-2 receptor subunit gamma gene (IL2RG), which was somatically reverted in T cells but not in natural killer ...

Till date, fourteen different types of SCID have been identified, the most common being X-linked SCID (XSCID), which is caused by a mutation in the IL2RG gene on X-chromosome. Other possible loci ...

Accordingly, immunological characteristics for IL2RG-linked X-SCID include the absence of T cells in the peripheral blood and lymphoid organs, with additional NK lymphocytopenia. Although B cell count ...