The main genes for the development of uterine fibroids can be 3 polymorphisms: IL1B-31TC, VEGF+936CT and IL10-592CA. These genes form the main nodes in the gene network because they have the most ...

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease ...

Acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) are cancers that originate from a type of white blood cell. AML features a rapid onset, and CML is slower to progress. Leukemia is a ...

Introduction: Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood.

Advancing drug development by leveraging microdissection for proteogenomic analysis of histological sections. Pathological evaluation of tumor immune microenvironment before first-line anti-PD1 plus ...

They also stimulated these cells with EC-activating agents, such as IL1b, TGFB2, or siEGR, to knock down this master transcription factor in ECs. The results show a subpopulation, EC3, with the ...

As a vital inflammatory cytokine, IL1B might drive a new tumor subtype that could be reflected in overall survival (OS) and predicted using the radiomics method. Methods: A total of 139 patients with ...

Part of this involved a focus on an inflammatory factor called interleukin 1 beta (IL1B), which is part of the body's natural immune response to pathogens and tissue damage. The scientists ...

Moreover, 5 hub genes (IL1B, TNF, and IRF1 are upregulated, HMGB1 and P2RX7 are downregulated) were identified via the PPI network and verified by a validation set. Then immune infiltration analysis ...