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A first clinical Ph2 trial with the anti-IL17A mAb secukinumab in patients with rotator cuff tendinopathy (NCT03344640) revealed clinically relevant and significant improvement of tendinopathic ...

A phase 2a study of NT-I7 (efineptakin alfa), a long-acting IL-7, and pembrolizumab to evaluate efficacy, including overall survival, in hard-to-treat gastrointestinal tumors. This is an ASCO Meeting ...

We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024 and rs2275913 in the IL17A gene; and rs3024498 in the IL10 gene. For the association analyses, we ...

Luminex (5-plex) assay for TB-specific cytokines: IL-17/IL17A, IFN-γ, TNF-α, IL-2 and GM-CSF was also performed on baby QFT plasma. Prism was used for statistical analysis, and P<0.05 was considered ...

The aim of this study was to investigate whether polymorphisms in the IL-17 (IL17A and IL17RA) genes, where IL-17 protein expression is linked to important physiological functions, could be associated ...

Recent evidence suggests that the interleukin −17 (IL17) axis strongly contributes to SpA. This study aimed to assess the efficacy of an IL17A peptide-based vaccine on SpA manifestations in model rats ...

IL17A also controls the immune responses against extracellular bacteria and fungi (3). IL17A is mainly produced by CD4 + Th17 cells. IL17A is also produced by other cells including CD8 + T cells, Yδ T ...

dTranslational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany ...