Objectives: Transforming growth factor β1 (TGFβ1)-interleukin 11 (IL11) is a newly found critical signaling pathway in fibrotic diseases such as Graves’ orbitopathy (GO). It has now been confirmed ...

Leveraging approaches across the translational spectrum, her group has identified targetable pathways leading to muscle wasting and cachexia, including GDF15, OSM/IL6;IL11/STAT3, ...

Scientists from Duke-NUS Medical School have discovered that the protein IL11 accelerates aging, and targeting it with anti-IL11 therapy can reverse signs of aging in preclinical models, increasing ...

“In other words, the old mice receiving anti-IL11 were healthier.” The treatment also mitigated pathologies caused by fibrosis, chronic inflammation, and impaired metabolism, all of which are ...

In other words, the old mice receiving anti-IL11 were healthier,” said co-corresponding author Professor Stuart Cook from the Medical Research Council Laboratory of Medical Science (MRC LMS), Imperial ...

Share on Pinterest Scientists are testing a drug that increased the lifespan and health of aging mice. BONNINSTUDIO/Stocksy Scientists have discovered that deactivating a protein called IL-11 can ...

Female Il11-deleted mice are protected from age-associated obesity, frailty, and metabolic decline. Male mice lives 22.5% longer and female mice 25% longer. The effects were similar to rapamycin but ...

In other words, the old mice receiving anti-IL11 were healthier. “Previously proposed life-extending drugs and treatments have either had poor side-effect profiles, or don’t work in both sexes, or ...

Scientists in Singapore have discovered that blocking the protein interleukin-11 (IL11) can counteract ageing effects in mice, extending their lifespans. Listen to Story A protein called IL11 promotes ...

The deletion of the IL11 gene was found to extend the lifespan of the mice by an average of 24.9%, and treatment of 75-week-old mice with anti-IL-11 antibodies increased the median lifespan of ...

In other words, the old mice receiving anti-IL11 were healthier." "Previously proposed life-extending drugs and treatments have either had poor side-effect profiles, or don't work in both sexes ...