Thus, the signaling pathways downstream of cGAS and RIG-I/MDA5 converge at the stage of TBK1/IKK. Following, IRF3 is recruited to the phosphorylated pLxIS motifs of STING or MAVS, leading to ...

Activated TBK1 phosphorylates the transcription factor IRF3 (interferon regulatory factor 3), leading to its dimerization and translocation to the nucleus. IRF3 induces the expression of type I ...

Perhaps there is a priority for Pellino1 to decide which pathway to participate in. IKK ϵ and TBK1 can enhance the activation of Pellino1 depending on IRF3 and K63-linked polyubiquitination of TBK1 ...

Subsequently, through the recruitment of TRAF proteins, MAVS activates two signaling pathways mediated by TBK1-IRF3 and IKK- NF-κb, respectively, and turns on type I interferon and proinflammatory ...

The facility was established under a memorandum of understanding signed in 2019 by New Zealand’s Pultron Composites, and its partner, Isam Khairy Kabbani Group (IKK), with Saudi Aramco. The ...

Q-B contains multiple factors known to be important for virus-induced IRF3 activation, such as NEMO, TBK1, ubiquitin, and E1 (data not shown). Q-B also contains the IKK complex; however, IKKα/IKKβ ...

In addition, IRF3-mediated gene expressions on lipopolysaccharide ... (IKK)ɛ, which phosphorylate IRF3 at several serine/threonine residues of its C-terminal trans-activation domain 13, 14.

IKKε (also called IKK-i) is the other noncanonical IKK involved in regulating the activation of the IRF3 and NF-κB signaling pathways . Upon activation in response to toll-like receptor agonists and ...