Conversely, IGFBP5 overexpression effectively rescued these oxidative stress phenotypes. Mechanistically, IGFBP5 downregulation attenuated extracellular signal-regulated kinase 1/2 (ERK1/2) ...

The major genetic risk factor for Alzheimer’s disease (AD), APOE4, accelerates beta-amyloid (Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or astrocytes is debated.

Figure 1. Data acquisition and workflow to train DEGAS using human pancreatic islet transcriptomic data for prediction of T2D-associated cells. A) Read count data for human islet bulk RNA-seq from ...

Su, Xiaoyu (PhD student, Bristol Medical School): Investigating the role of ERβ and IGFBP5 in the inhibitory effects of oestrogen receptor modulators in colon cancer Waterfield, Scott (PhD student, ...

our study found that Mybbp1a suppressed the transcription of IGFBP5 through the DNMT1-mediated hyper-methylation level of CpG islands in the IGFBP5 CDS site. This biological process led to a loss of ...

First, we validated that IGFBP5 was significantly increased among the mRNA, intracellular protein and extracellular protein levels under Mybbp1a knockdown in Huh7 cells (Fig. 5 b).Then, we analyzed ...

(D) qPCR analysis of the expression levels of Eng, Cd74, Igfbp5, Cxcl14, Cd14, and Cxcl2 in CD105 pos and CD105 neg CAFs. CD105 pos and CD105 neg CAFs were isolated from five LLC tumors and pooled to ...

Hepatic expression of IGFBP5 and IGFBP6 mRNA, were greater while IGF1 and IGFBP3 mRNA tended to be greater for Post-TMR than PG cows. Hepatic expression of IGF1, IGFBP5 and IGFBP6 mRNA increased from ...

Su Xiaoyu (PhD student, Bristol Medical School: Translational Health Sciences, University of Bristol): Investigating the role of ERβ and IGFBP5 in colorectal cancer The prizes We are delighted to have ...

Once fused with IGFBP5, ALK may function synergistically with IGFBP5 to trigger different signaling outputs that drive the initiation and progression of uterine IMT. However, the definite role and ...