A small protein called ISG15 attaches to these sites – a process termed ISGylation, explains the study's first author Lucky Sarkar, PhD, a postdoctoral researcher in Dr. Gack's lab. To explore ...

In this important study, the authors employed state-of-the-art biochemistry, cryo-EM, and HDX mass spec approaches to study the formation of the binary Uba7-UBE2L6 and ternary UBA7-UBE2L6-ISG15 ...

Researchers in this recent study paid particular attention to the ISG15 gene, which is associated with a severe course of COVID-19 in humans. Bats are known to carry numerous viruses, including those ...

Researchers in this recent study paid particular attention to the ISG15 gene, which is associated with a severe course of COVID-19 in humans. Bats are known to carry numerous viruses, including ...

Researchers in this recent study paid particular attention to the ISG15 gene, which is associated with a severe course of COVID-19 in humans. Bats are known to carry numerous viruses, including ...

Bats harbor many viruses that can spill over into humans, including Marburg, Ebola, and famously SARS-CoV-2. But while these viruses often cause severe illness in humans, they do not appear to ...

Shoji's team previously worked on the immune response to hepatitis viruses and investigated the role of a molecular tag called "ISG15" the innate immune system attaches to the virus's building blocks.

We analyzed interferon-stimulated gene 15 (ISG15) expression in dopamine-treated cells. We knocked down ISG15 and then monitored HBsAg and HBeAg expression levels. We analyzed the expression of ...

intermedia. Transcriptome and immunohistochemical analyses revealed that P. intermedia infection increased the expression of interferon-stimulated gene 15 (ISG15). Correlation analysis indicated that ...

The attachment of the ubiquitin-like protein ISG15 to substrates by specific E1-E2-E3 enzymes is a well-established signalling mechanism of the innate immune response. Here, we present a 3.45 Å ...

Dorayappan, K. D. P., Wagner, V., Park, D., Newcomer, M. M., Lightfoot, M. D. S., Kalaiyarasan, D., Sakaue, T., Khadraoui, W., Yu, L., Wang, Q. E., Maxwell, G. L., O ...