A recent study published in Cardiovascular Diabetology reveals that Sacubitril/Valsartan, a combination of a neprilysin ...

“I Have Never Been More Afraid for My Country’s Future,” by Thomas L. Friedman (column, April 17), is an alarm we all need to hear. His main point couldn’t be clearer: The things that have ...

Gene expression analysis identified key markers, including Jun Proto-Oncogene (JUN) and Interferon Regulatory Factor 7 (IRF7), associated with regulating immune response and improving tumor ...

Background and aims Previous study identified rs1131665 in IRF7 associated with SLE among multiple ethnic groups. This study was undertaken to investigate whether other genetic polymorphisms within ...

Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 ...

Short-term inactivation of Adar1 attenuates cardiac hypertrophy upon pressure overload due to induction of IRF7 expression before initiation of inflammatory cardiomyopathy. Autoinflammatory processes ...

In a recent study posted to the bioRxiv* preprint server, researchers assessed the roles of the interferon (IFN) regulatory factors (IRFs): IRF1, IRF3, and IRF7 in infections by human ...

Furthermore, our results showed that SVA might be recognized by RIG-I/MDA-5 receptors first after infecting PK-15 cells and then activates downstream IRF7-mediated signaling pathways, causing an ...

Reduced levels of NMI also resulted in increase of the expression of IRF7. Further studies have revealed that NMI could interact with IRF7 after IAV infection, and this interaction involved with its ...

Herein, we demonstrated that DENV and CHIKV infected cells are sensed by pDCs, indirectly, resulting in selective IRF7 activation and IFN-I production, in the absence of other inflammatory cytokine ...

Thank you for submitting your article "Plasmacytoid Dendritic Cells Control Dengue and Chikungunya Virus Infections via IRF7-regulated interferon responses" for consideration by eLife. Your article ...

As a proof of principle, the authors further demonstrated that the exposure of microglia to IFNβ, a known inducer of Irf7, could induce the switch from M1‐ to M2‐phenotype in the LPS tolerance model.