Home Irish WNT need 2 wins. Irish international Katie McCabe celebrates with the cup following Arsenal’s UEFA Women’s Champions League final win in Lisbon last weekend. [Inpho/Jose Breton] Irish WNT ...

Background: Aberrant accumulation of dsDNA in tumour cells activates the cGAS-STING pathway, playing a crucial role in anti-tumour immunity. However, the role of the dsRNA sensor RIG-I-like ...

IRF3 is a key transcription factor required for the antiviral innate immune response. After receiving the upstream TBK1 signal, IRF3 activates type I IFN signaling through multiple processes, ...

A new study reveals why some pancreatic and colorectal tumors resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to patients with fully treatment-resistant cancers.

A Wnt/β-catenin pathway agonist under development by Surrozen appears to be effective against idiopathic pulmonary fibrosis (IPF) in mouse models, according to new data.. The results, published ...

Wnt proteins induce signalling when they bind to a membrane receptor complex comprising a Frizzled (Fz) G-protein-coupled receptor and a lipopolysaccharide-like receptor protein 5/6 (LRP5/6).

Activation of WNT signaling has been associated with cancer immune-suppression and resistance to immunotherapy. Methods: The first-in-human trials (NCT02675946 in U.S., NCT03507998 in China) include ...

Researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation. The findings shed light on the ...

The IRF7, IRF3, and IRF1 levels elevated from two days of HCoV-OC43 infection. Similarly, the IRF7, IRF1, and phospho-IRF3 levels hiked after two days of SARS-CoV-2 infection.

Wnt signaling controls both development and homeostasis, and its disruption is implicated in a wide range of human diseases. 6-10 The human genome encodes 19 Wnt ligands, which have unique and yet ...

The Wnt pathway plays a wide variety of roles in animal and human development, and the ability to regulate it with light will allow researchers to better study its assorted functions.