Interferon regulatory factor 3 (IRF3)‐induced type I interferon (I‐IFN) production plays key roles in both antiviral and autoimmune responses. IRF3 phosphorylation, dimerization, and nuclear ...

The abbreviation cGAMP denotes cyclic guanosine monophosphate–adenosine monophosphate, IRF3 interferon regulatory factor 3, mRNA messenger RNA, and STAT signal transducer and activator of ...

IRF3 denotes interferon regulatory factor 3, IκBα nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor alpha, NF-κB nuclear factor κB, and TBK1 TANK binding kinase 1.

A group of researcher in Italy looked into the relationship between interferon regulatory factor 3 (IRF3) and COPD outcomes. Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity ...

These included IRF3, which Monroe suspects might dictate the microglial shift into the interferon-responsive state, and E2F, which could push the cells into a cell cycling state. Which master ...

Regarding miR-374b-5p, it was positively correlated with AKT and EDSS. In conclusion, the study showed for the first time that the crosstalk between MAGI2-AS3 and miR-374b-5p could affect the AKT/IRF3 ...

Results: Our data show increased mRNA levels of IRF3 in muscle atrophy model. Characterization of skeletal muscle-specific IRF3 transgenic mice showed activation of genes regulating IFN-1 pathway ...

Patients with high-risk pathology who received adjuvant pembrolizumab had a 1-year relapse rate of 16.7%, which compares favorably with historical data in similar patients. 27 Interestingly, patients ...

In a recent study posted to the bioRxiv* preprint server, researchers assessed the roles of the interferon (IFN) regulatory factors (IRFs): IRF1, IRF3, and IRF7 in infections by human ...