Idaho police found a three-person mixture of DNA under the fingernails of Madison Mogen's left hand, according to court filings, but testing was inconclusive.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The cytosolic nucleic acid sensors RIG-I and ...

Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006;24:93-103. Crossref. PubMed. Web of Science. Google Scholar. 4.

Figure 1 Overview of DDR components in innate immune responses. DDR factors, including DNA-PK and MRE11, promote cytosolic DNA sensing signaling pathways. When activated by cytosolic DNA, cGAS ...

HIV-1 Vpr antagonises innate immune sensing of viral and non-viral stimuli by preventing activated IRF3 and NF-κB nuclear transport. Skip to Content. eLife home ... expression for 48 hr did not impact ...

Unfortunately, the antibody used to detect IRF3 phosphorylation at S396 by flow cytometry (Cell Signaling D6O1M) did not work well in immunoblots in our hands. Further, the antibody detecting IRF3 ...

AGO2 did not block phosphorylation, nuclear translocation, and DNA binding ability of IRF3 but inhibited its association with CBP. Therefore, this newly revealed mechanism shows that cellular response ...

Given the importance of STING–IRF3 signaling in inflammation, we examined its role in metabolic stress–induced endothelial inflammation. We found that palmitic acid (PA), by inducing mitochondrial ...

Given the importance of STING–IRF3 signaling in inflammation, we examined its role in metabolic stress–induced endothelial inflammation. We found that palmitic acid (PA), by inducing mitochondrial ...

Cytosolic DNA–mediated activation of the transcription factor IRF3 is a key event in host antiviral responses. Here we found that infection with DNA viruses induced interaction of the metabolic ...

Foreign nucleic acids trigger innate immune sensors. Bowie and colleagues identify the PYHIN protein IFI16 as an innate duplex DNA sensor that triggers IFN-β production in a STING-TBK1-IRF3 ...