A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring immune cells by secondary messengers ...

Get Instant Summarized Text (Gist) SMYD3 acts as a negative regulator of type I interferon signaling by catalyzing the dimethylation of IRF3 at lysine 39. This modification inhibits IRF3's ...

Viral infection activates the transcription factors IRF3 and NF-κB, which induce type I interferon (IFN) and antiviral innate immune responses. Here, we identify dual-specific tyrosine phosphorylation ...

They further identified another cellular mechanism, TBK1-IRF3, regulating IL-33 expression in chronic pancreatitis and dermatitis in mice. Researchers then tested the use of pitavastatin to block ...

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Using cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. Mechanistically, IRF3 ...

In a recent study posted to the bioRxiv* preprint server, researchers assessed the roles of the interferon (IFN) regulatory factors (IRFs): IRF1, IRF3, and IRF7 in infections by human ...

Using mouse models, they found that an innate immune response molecule called interferon regulatory factor 3 (IRF3), which is highly active in the liver during high-fat diet consumption, directly ...

Interferon regulatory factor 3 (IRF3)‐induced type I interferon (I‐IFN) production plays key roles in both antiviral and autoimmune responses. IRF3 phosphorylation, dimerization, and nuclear ...

A in-depth study showed that US3 protein restricted type I IFN production by targeting interferon regulatory factor 3 (IRF3), a key molecule required for type I IFN induction. Additionally, US3 ...

Here, we show that both particle associated, and expressed HIV-1 Vpr, antagonize the stimulatory effect of a variety of pathogen associated molecular patterns by inhibiting IRF3 and NF-κB nuclear ...