We enrolled 50 patients with MCL in this single-institution, single-arm, phase II clinical trial (NCT01880567). Patients with Ki-67% ≥ 50% and blastoid morphology were excluded. Ibrutinib was ...

12 Similar findings were noted in a Chinese population study. 13 A higher frequency of the rs2104286(G) allele in the IL2RA gene was observed in patients with NMOSD than in healthy subjects in a ...

Multiple sclerosis isn’t inherited, but having a family member with the disease can increase your chance of having the condition. While genetics influences your risk, environmental factors also ...

L19-TNF is composed of human recombinant tumor necrosis factor-alpha. The drug candidate acts by targeting fibronectin and interleukin 2 receptor subunit alpha (IL2RA). Philogen is a biotechnology ...

L19-TNF is composed of human recombinant tumor necrosis factor-alpha. The drug candidate acts by targeting fibronectin and interleukin 2 receptor subunit alpha (IL2RA). Philogen is a biotechnology ...

To do so, the team looked at a common protein called IL2RA, which is abundant on the surface of activated T cells. They wanted to see how the levels of this protein change in response to various ...

To do so, the team looked at a common protein called IL2RA, which is abundant on the surface of activated T cells. They wanted to see how the levels of this protein change in response to various ...

Researchers from Regeneron Pharmaceuticals Inc. have described REGN-10597 (PD1-IL2Ra-IL2), a programmed cell death protein 1 (PD-1)-targeted, receptor-masked IL-2 immunocytokine.

IL2RA, contains an intronic enhancer that is active in both lymphoid and myeloid cells. JIA-associated genetic variants identified by WGS attenuate or abolish enhancer activity at this locus. These ...

In the ADA group, clinical response was mainly associated with lower levels of pBMs such as IL6, TNFRSF1A, MMP10, IL2RA, PLAUR, CCL2, TNFRSF10C, and SERPINE1, suggesting that control of these pathways ...

Elevated levels of the cytokines PTX3, IL34, IL2RA, CCL23, and VEGFA correlate with active AAV. Increased levels of specific cytokines, such as PTX3, IL34, IL2RA, CCL23, and VEGFA, correlate with ...