Hitgen Ltd. has prepared and tested interleukin-17 receptor A (IL17RA; CD217) antagonists reported to be useful for the treatment of autoimmune disease, cancer, infections, asthma, multiple sclerosis, ...

2 Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan 3 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan Objective To ...

Results: We identified a novel bi-allelic variant (NM_014339.6, c.1173C>G A) within the interleukin 17 receptor type A (IL17RA) gene, resulting in a premature stop codon (p. Tyr391Ter). Despite the ...

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Concept: Microbial dysbiosis-induced Th17 and B cells synthesize and distribute IL17 to distant tumors. Impact: These results show that inhibition of IL17-IL17RA signaling could abrogate systemic ...

RPE-specific deletion of the IL-17 receptor A (IL17RA) caused dysfunction of both the RPE and subretinal microglia. The data collectively indicate that the RPE can relay the cytokine signals from γδ T ...

Treg regions were determined by a threshold of adjusted P<0.05 calculated by DESeq2. F. Genomic track showing the chromatin accessibility of Ifng, Il4, Il17ra, Il21. G. Genomic track showing the ...

Polymorphisms in the IL17A and IL17RA genes were evaluated from DNA in saliva, comparing individuals with or without Fanconi anemia, using models of genotypic transmission (additive, dominant, and ...

The aim of this study was to investigate whether polymorphisms in the IL-17 (IL17A and IL17RA) genes, where IL-17 protein expression is linked to important physiological functions, could be associated ...