Cross-talk between sterol metabolism and inflammatory pathways has been demonstrated to significantly affect the development of atherosclerosis. Cholesterol biosynthetic intermediates and derivatives ...

Psoriasis is a chronic inflammatory skin condition that affects 0.11%-1.58% of people globally. There are multiple types of psoriasis, of which plaque psoriasis is the most common, affecting up to ...

Despite the long history of psoriasis and psoriatic arthritis (PsA), until recently, little had been known of their underlying genetics and pathogenesis. Without this knowledge, rational clinical ...

Circadian rhythms exert a profound impact on most aspects of mammalian physiology, including the immune and cardiovascular systems. Leukocytes engage in time-of-day–dependent interactions with the ...

This important work reports on the transcriptomic analysis of leukocytes in the brain of adult zebrafish. A specific novel finding is the identification of dendritic cells distinct from microglia or ...

cSt Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York City, NY, USA dSchool of Life Sciences, École Polytechnique Fédérale de Lausanne ...

Increased expression of IL17A, IL17F, or IL23A contributes to a favorable prognosis of HNSCC. In the tumor microenvironment of HNSCC, IL23A and IL12B are expressed in mature dendritic cells enriched ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Increased lactate levels in the tissue ...

Candidate biomarkers for disease progression in psoriasis have been identified, according to a review published online April 28 in the British Journal of Dermatology. Ravi Ramessur, B.M.B.S., from ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Psoriasis is a complex chronic inflammatory ...

The results showed that the SNPs in 5q33.3, 1p36, and 1q21.3 are strongly associated with PsA, and IL12B, RUNX3, and LCE are candidate genes for these regions. Yang et al. (2013) genotyped 20 SNPs in ...

Molecular biomarkers for multiple sclerosis have so far mainly been limited to measures in cerebrospinal fluid (CSF). Here, we identified additional biomarkers for multiple sclerosis, 2 in plasma as ...