Moreover, we measured the serum levels of the anti-dsDNA antibody, IL-6 and IFN-γ, which are also hallmarks of lupus progression. As expected, the ELISA results showed that the concentrations of the ...

The role of interleukin 6 (IL-6)-mediated signalling in the expression of progranulin was assessed using a combination of specific inhibitors and shRNA knockdown techniques. The effect of progranulin ...

To this end, we inhibited the ERK or PI3K/Akt pathway with PD98059 (ERK inhibitor) or LY294002 (PI3K/Akt inhibitor) and observed an overall decrease in IL-6 production in DNCB-treated keratinocytes .

Exogenous IL-6 mediates cardiomyocyte mitochondrial damage and bioenergetics impairment through inhibition of the Akt/mTOR signaling pathway. (A–D) Cardiomyocytes were treated with exogenous IL-6.

Rationale: It has been reported that interleukin (IL)-1 is associated with pathological cardiac remodeling and LV dilatation, whereas IL-1β has also been shown to induce cardiomyocyte hypertrophy.