Objectives There is growing evidence for the role of systemic inflammation in Alzheimer’s disease (AD) and other neurodegenerative diseases; however the systemic inflammatory profile in dementia with ...

The standard has been set. Over just the past five seasons, Illinois has won a Big Ten regular season title, two conference tournament championships, a No. 1 seed in the NCAA Tournament and made ...

IL-12p70 is a potent stimulator of the immune system with profound anti-tumor activity but very poor tolerability. Mural is developing an innovative approach to mitigate that toxicity by creating ...

IL-12p70, composed of p35 and p40 subunits, is a proinflammatory cytokine produced primarily by antigen-presenting cells and mediates type 1 helper T cell (Th1) differentiation. In neurobehavioral ...

We designed a 2‐sample MR approach to evaluate the potentially causal effects of circulating cytokines and growth factors on CAD (). 14, 15 Genetic variants associated with CAD were obtained from a ...

IL-2 and IL-12 are cytokines that activate cytotoxic CD8+ T cells and natural killer (NK) cells. IL-12 is a heterodimer existing as two isoforms, IL-12p40 and IL-12p70, the latter being less abundant.

Bioactive IL-12p70 heterodimers, composed of IL-12p35 and IL-12p40 subunits, are released into the circulation by macrophages and thereby stimulates natural killer (NK) cells. Eventually, activated NK ...

Stem cells are a vital component of regenerative medicine therapies, however, only a fraction of stem cells delivered to the central nervous system following injury survive the inflammatory ...

Blood sampling data showed that people who recovered from COVID-19 had high systemic cytokine deregulation, including elevated levels of TNF-α, TNF-β, IL-1β, IL-6, IL-8, and IL-12p70.

The antibody against IL-12p35 also cross-reacted to the commercially available human recombinant IL-12p70 (p35/p40) with its degradation (Figure 2(b)). However, the antibody against IL-12-p35 detected ...

The objective of the current Mendelian randomization study was to explore the effect of genetically predicted tumor necrosis factor (TNF)-α, IL-12p70, and IL-17 levels on risk for PsA. Using ...