Osteoarthritis (OA), a whole-joint disease driven by abnormal biomechanics and attendant cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence, representing a ...

ABSTRACT: Background and Objectives: Increased expression of the CD97, nuclear factor-kB (NF-kB) and cyclooxygenase-2 (COX-2) has been found to play an important role in development of many cancers, ...

BACKGROUND: Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. Apart from Parkin, little is known about additional Ub (ubiquitin) ligases that mediate mitochondrial ...

The autophagic system targets impaired mitochondria and delivers them to lysosomes for degradation. This catabolic process, called mitophagy, contributes to maintaining mitochondrial quality control ...

Interactions of developing T cells with Aire + medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEC hi) are critical for the induction of central tolerance in the ...

Celastrol bears a chemically reactive quinone methide moiety and thereby tends to form covalent conjugate with certain proteins such as HIV-Tat, IKKalpha, and beta kinases, Cdc37 and HSF although such ...

Figure 1 Activation of canonical NF-κB signaling and non-canonical NF-κB signaling.(A) Canonical NF-κB signaling is stimulated by proinflammatory cytokines such as IL-1β, TNF-α and LPS, inducing the ...

21. Srivastava R, Burbach BJ, Shimizu Y. NF-kappaB Activation in T Cells Requires Discrete Control of IkappaB Kinase Alpha/Beta (IKKalpha/beta) Phosphorylation and IKKgamma Ubiquitination by the ADAP ...

Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, et al. Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the ...

N 6 ‐methyladenosine (m 6 A) modification of mRNA mediates diverse cellular and viral functions. Infection with Epstein–Barr virus (EBV) is causally associated with nasopharyngeal carcinoma (NPC), 10% ...