These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Diffuse Large B-Cell Lymphoma Companies are involved in targeted therapeutics development with respective active and inactive ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

RNA-sequencing, histone 3 lysine 27 acetylation (H3K27ac), chromatin immunoprecipitation-sequencing (ChIP-seq) and assay for transposable accessible chromatin by high throughput sequencing (ATAC-seq) ...

Here, we sought to identify specific histone demethylases that are involved and delineate the underlying mechanisms. Conclusions These findings indicate that knockdown of Kdm6b in chondrocytes leads ...

Examples include DNA methylation and histone acetylation, which can turn genes on or off. Despite their differences, both mechanisms contribute to molecular aging. Researchers have long speculated ...

Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Pharmaceutical Sciences, Central University of Punjab, Bathinda 151 401, India ...

Acetylation of these amines with acetyl transferases converts amines to N-acetyl amines (acetamides) and stops the formation of the positive charges. On the other hand, deacetylation of acetamides ...

To clarify the function of histone acetylation in immune response after transplantation, butyrate (10 mmol/L) was used for the treatment of pearl oysters before transplantation. Results showed that ...

Mechanistically, 8C reduced I/R injury by promoting histone acetylation which in turn activated the expression of antioxidant genes and inhibited cardiomyocyte (CM) apoptosis. Furthermore, we ...