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(10) It was thus clear that reduction of hERG in this series would require judicious modification of these structures. Data are the geometric mean of two independent experiments (n = 2) unless ...

Many drugs from different chemical classes and therapeutic areas have been shown to inhibit currents mediated via the hERG-coded ion channel, which is strongly correlated to a risk of inducing TdP.

Generation of hERG channel models in the closed (a), open (b), and inactivated (c) states. The lower limit of the pore radius color profile (1.15 Å) indicates the minimum radius to accommodate a water ...

However, little is known about how reduced glycosylation impacts the gating of hERG ( human ether-a-go-go related gene) channel, which is partially responsible for late phase 2 and phase 3 of the AP.

Fun to ride and very capable in all conditions, the Aventon Aventure.2 is an excellent multi-surface commuter bike that you’ll be happy to have in winter conditions. The brake lights and turn ...

Long QT syndrome type 2 (LQT2) is a genetic disorder caused by mutations in the KCNH2 gene, also known as the human ether-a-go-go-related gene (hERG). Over 30% of hERG mutations result in a premature ...

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