Despite our relatively rudimentary understanding of the ovarian cancer epigenome, there is increasing interest in the utilization of epigenetic therapies in the treatment of this disease, as well ...

The expression of patterning genes Meis homeobox 1 and 2 (Meis1, Meis2), homeobox A cluster genes (Hoxa9, Hoxa11, Hoxa13), and short stature homeobox (Shox, Shox2) was evaluated.

Stomach adenocarcinoma (STAD) is a subtype of gastric cancer with high incidence and mortality. Lack of early detection results in the poor prognosis of this cancer, leading to low survival rate of ...

Results: We found an increase in expression of genes involved in the cell cycle in the EOCRC cohort, and of specific genes (e.g. HOXA11-AS, STMN2) involved in cell proliferation and metastasis.

Analysis of Concordance Between Next-Generation Sequencing Assessment of Microsatellite Instability and Immunohistochemistry-Mismatch Repair From Solid Tumors ...

Objectives This study was directed towards exploring the impacts of lncRNA HOXA11-AS-mediated microRNA (miR)-506-3p on chondrocytes proliferation and apoptosis in osteoarthritis (OA). Methods The ...

Scientists discovered that two genes, hoxa11 and hoxa13, form fish and human fin rays. According to a University of Chicago study, these genes, essential for fish fin ray production, also develop ...

HOXA11 was found to inhibit Wnt signaling by upregulating NKD1 expression. Conclusion: Epigenetic silencing of HOXA11 promotes GC proliferation, migration and invasion through activation of Wnt ...

As HOXA11-AS was demonstrated to promote cellular proliferation and tumorigenesis, we propose that real-time regulation of HOXA11-AS-involved integrated network in keloid fibroblast might be ...

DNA methylation dysregulation during carcinogenesis has been widely discussed in recent years. However, the pan-cancer DNA methylation biomarkers and corresp ...