Type 1 diabetes (T1D) is an autoimmune condition where the immune system destroys insulin-producing β-cells in the pancreas. Yet, not all patients lose insulin function at the same pace. Understanding ...

Arthritis is among the most prevalent chronic diseases on the planet, but did you know it occurs in women more than men? The CDC reports that nearly 1 out of 4 adult women in the U.S. have arthritis ...

Further investigation has targeted C-reactive protein, GMCSF and a various of markers in the HLA family, including HLA-B27 and HLA-DR4, with similar results.

The exact cause is unclear, but genetic, environmental, and immune system factors contribute to RA development. Genetics plays a significant role as genes such as HLA-DR4 raise the chances of RA.

Our findings suggest islet transplantation from HLA-DQ8 donors is associated with superior graft outcomes. A donor positive for HLA-DQ2-DQA1∗05 at first transplant was associated with inferior graft ...

And I discovered that, indeed, it was actually a particular HLA that was protective against Parkinson’s disease that’s called HLA-DR4, that about 30% of the population has.

In addition, patients are required to have a biopsy sample of tumor available for analysis of programmed PD-L1 expression, be HLA-A2 positive, be positive for HLA-DR4, HLA-DR7, HLA-DR53 or HLA-DQ6, ...

The distribution of tri-SNP haplotypes and HLA genotypes is shown in Table 1. As anticipated, given the study inclusion criteria, most (N=7503) participants were homozygous for either DR3 or DR4, ...

In the case of T1D, HLA genotyping can identify persons at risk for the disease, but only about 1 in 15 (∼7%) individuals with even the highest-risk HLA genotype identified in Europeans (HLA-DR3/DR4 ...

DR4 is one among copious alleles of a gene called DRB1, which itself is one among many in a large complex of genes — called the human lymphocyte antigen complex, or HLA — that’s crucial to ...

DR4 is one among copious alleles of a gene called DRB1, which itself is one among many in a large complex of genes -- called the human lymphocyte antigen complex, or HLA -- that's crucial to ...