Success rates were highest for HLA-matched units, at 48.3%, followed by cross-matched units at 35.3%, and random units at 22%. A recent retrospective study highlighted the importance of human ...

Read the full paper published in Science Immunology, titled Crystal Structure of the Human LAG-3–HLA-DR1–Peptide Complex About the Monash Biomedicine Discovery Institute Committed to making the ...

Interestingly, HLA-DR1, DR7 and DQ5 were protective alleles, with DR7 and DQ5 remaining protective after accounting for PSC. Furthermore, although CIITApIV methylation itself was not associated with ...

Rheumatoid arthritis (RA) is a clinical diagnosis that relies heavily on the history of articular and extraarticular manifestations and joint examination; these are supplemented by results of ...

Objective We sought to identify human leukocyte antigen (HLA)-DR1-restricted epitopes from the Timothy grass pollen allergen, Phleum pratense, and characterise T-cell immune regulation following ...

In the recent study, the MedUni Vienna researchers demonstrated for the first time that, in four mouse models, only mice with the HLA-DR1 gene were capable of developing an allergy to mugwort.

but this risk is reduced to baseline in the presence of the protective HLA allele HLA-DR1. “The basis of the loss of immunological tolerance in most autoimmune diseases lies in the inheritance ...

Another molecule, called HLA-DR1, has also been linked to a number of autoimmune conditions. What the researchers didn't know until now is what the mechanism of these molecules actually was, and why ...

HLA matching provides numerous benefits in organ transplantation ... encodes the relatively invariant α chain and a DRB1 gene that encodes the β chain of the DR1-DR18 antigens. Some haplotypes carry ...

EULAR moderate or good response to TNF inhibitor therapy was 86% in homozygote carriers of valine at position 11 in HLA-DR1, 81% in heterozygote carriers, and 78% in noncarriers (odds ratio ...

highlighted by two recently solved co-structures of HLA-DM bound to HLA-DO (a natural inhibitor of HLA-DM), or to HLA-DR1 (a common MHCII). In light of these efforts, a model for HLA-DM action in ...