Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic musculoskeletal disease that predominantly affects the ...

The strongest risk factor for developing ankylosing spondylitis involves carrying the HLA-B27 gene variant, found in approximately 90% of people with the condition. However, only 5% of people who ...

There have also been genetic studies that suggest the fold is related to HLA-B27 and C3-F genes and chromosome 11, while other work has indicated that Frank’s Sign could be associated with ...

Human leukocyte antigen B27 (HLA-B27) positivity was associated with higher odds of non-remission in patients with juvenile idiopathic arthritis (JIA) at 18 years after disease onset, with men ...

Initially, the focus will be on treating axial spondyloarthritis (AxSpA) and potentially other immune and inflammatory conditions associated with HLA-B27. The investment will also support the ...

This link may relate to the presence of the HLA-B27 gene. EDS is a rare genetic condition that affects connective tissue. AS is a form of arthritis that causes inflammation in the spine.

Patients with late-onset axial spondyloarthritis (axSpA) are less likely to be positive for human leukocyte antigen B27 (HLA-B27) and have a family history of SpA; they are more likely to present ...

Most people who have ankylosing spondylitis have a gene that makes a protein or "genetic marker" called HLA-B27. This gene is involved in your body's immune response, which normally works to ...

Genes and environmental exposures probably trigger AS, too. People who have a gene called human leukocyte antigen (HLA)-B27 are at higher risk. HLAs help your immune system tell your own cells ...

Research has shown about 75% of people who inherit the HLA-B27 gene do not develop AS. Genetic testing can be a helpful tool for identifying your risk. A healthcare provider may refer you to a ...

It’s not exactly clear, but many people with the condition have a gene called HLA-B27. One theory is that when people with this gene are exposed to a trigger—like a particular virus or ...