The HIV-1 accessory protein Vpu was found to be responsible for the cleavage of TDP-43, as ectopic expression of Vpu alone was sufficient to induce TDP-43 cleavage, whereas HIV-1 lacking Vpu failed to ...

BST2/tetherin is a restriction factor that reduces HIV-1 dissemination by tethering virions at the cell surface. Its action is counteracted by the viral protein Vpu through multiple mechanisms. Here, ...

In addition, nnAbs have been shown to eliminate HIV-1-infected cells via antibody-dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in a vaccine trial. A vpu ...

Fatal lack of expression “We observed that the modified HIV-1 virus used in certain laboratory experiments does not express Vpu,” said Finzi. “However, in the naturally occurring virus ...

Concerning size, position in the membrane, ion channel activity, and roles to promote virus release, CoV E proteins resemble the viral protein U (Vpu) of HIV-1. Because of these similarities ...

Phenotypical Characterization of PBMCs From Healthy and HIV-1-Infected Individuals PBMCs from healthy and ... Invitrogen) with specific Vpu outer-revers primer (sense primer: 5’-CCT AGA CTA GAG CCC ...

To counter this measure, HIV and SIV make a protein called viral protein U (Vpu) that attaches to tetherin and blocks its effects. “Because viruses adapt to their hosts, HIV Vpu is most effective ...

HIV is responsible for acquired immunodeficiency ... More information: Weitong Yao et al, Vpu of a Simian Immunodeficiency Virus Isolated from Greater Spot-Nosed Monkey Antagonizes Human BST ...