“These findings support the idea that HDAC6 is a promising drug target for treating liver fibrosis. “We are also starting to understand more about how these compounds work at the molecular level, ...

Background: Lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6) are epigenetic proteins associated with several diseases, including cancer. JBI-802 is a highly potent CoREST ...

AGT-100216 is the first HDAC6 inhibitor from Augustine's pipeline to enter clinical trials. LEUVEN, Belgium - 27 May 2025- Augustine Therapeutics NV ("Augustine” or "the Company”), a biotechnology ...

HDAC6 inhibitor ITF-3756 targets multiple immune checkpoints. May 14, 2025. No Comments. Tumor immunotherapy has become a standard of care for treating various cancers, with immune checkpoint ...

Treating the liver slices with HDAC6 inhibitors greatly reduced signs of fibrosis, showing that these compounds can stop – and possibly even reverse – the scarring process at the cellular level.

HDAC6 is involved in neurodegeneration and tissue aging-related cellular processes, and pharmacologic inhibition of HDAC6 is a promising approach in a number of diseases. Augustine Therapeutics have ...

Highly selective Small Molecule HDAC6 Inhibitor Effectively Reversed Heart Failure and Improved Diastolic Heart Function Alone or in Combination with SGLT2 Inhibitor in Murine Models of Disease ...

HDAC6 inhibition was shown to restore hypertrophy, fibrosis and mitochondrial energy production. TYA-018 demonstrated greater impact on markers of oxidative stress, ...

AVS100 is a highly selective, orally bioavailable, isoxazole-3-hydroxamate based HDAC6 inhibitor. AVS100 demonstrated unique ability in its class preclinically in suppressing the polarization of ...

Microtubule acetylation and impaired axonal transport have been proposed as mechanisms causing amyotrophic lateral sclerosis (ALS). Furthermore, histone deacetylase 6 (HDAC6) is known to play a role ...

When HDAC6 is dysfunctional, abnormal cellular responses result, leading to pathology. HDAC6 has been implicated in multiple diseases, including cancer and neurodegenerative diseases.